|
The genetic architecture of hybrid male sterilityCharles Darwin called speciation the “mystery of mysteries.” I am interested in understanding this great mystery through the lens of postzygotic reproductive isolation. I leverage large-scale genomic datasets, laboratory crosses, and forward evolution experiments to study the genetic architecture of hybrid sterility in the house mouse subspecies Mus musculus domesticus and M. m. musculus.
|
THE CONTRIBUTION OF DIFFERENT LEVELS OF GENE REGULATION on PHYLOGENETIC TIMESCALESRecent studies have identified a major role for regulatory changes in phenotypic evolution. However, much of the research in this area has focused on transcriptional regulation while the role of post-transcriptional changes has remained largely ignored. Using a variety of molecular techniques combined with next-generation sequencing, I am characterizing the contribution of different levels of regulatory divergence to phylogenetic divergence in the Muridae.
|
THE ROLE OF GENE REGULATION
|