Katya L. Mack
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  • Research Interests
  • CV
  • Publications
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​the role of regulatory evolution in speciation and adaptation

As a graduate student in the Nachman lab, my work currently focuses on house mice (Mus musculus). House mice are a premier biomedical model system and a powerful mammalian model for the study of adaptation and speciation.

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​The genetic architecture of hybrid male sterility

Charles Darwin called speciation the “mystery of mysteries.” I am interested in understanding this great mystery through the lens of postzygotic reproductive isolation. I leverage large-scale genomic datasets, laboratory crosses, and forward evolution experiments to study the genetic architecture of hybrid sterility in the house mouse subspecies Mus musculus domesticus and M. m. musculus. 
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THE CONTRIBUTION OF DIFFERENT LEVELS OF GENE REGULATION on PHYLOGENETIC TIMESCALES

Recent studies have identified a major role for regulatory changes in phenotypic evolution. However, much of the research in this area has focused on transcriptional regulation while the role of post-transcriptional changes has remained largely ignored. Using a variety of molecular techniques combined with next-generation sequencing, I am characterizing the contribution of different levels of regulatory divergence to phylogenetic divergence in the Muridae.
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​THE ROLE OF GENE REGULATION
​IN Adaptation

Mus musculus domesticus has recently colonized the Americas and can be found in extremely variable environments from Alaska to Tierra del Fuego. Together with others in the Nachman lab, I am working to characterize gene expression variation in natural populations of house mice as well as the the role of gene regulation in clinal adaptation in North America.
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